The targeting of Flt3, c-Kit and Src as therapies for c-Cbl-associated myeloid malignancies [ 2012 - 2014 ]

Research Grant

Researchers: Prof Wallace Langdon (Principal investigator)

Brief description Most leukaemias are incurable so it is important to find new treatments. For this to occur it is essential that the mutated genes causing leukaemia are identified. We have generated a mouse with a mutation in a gene, c-Cbl, that promotes the activation of a number of proteins involved in leukaemia development. By treating c-Cbl mutant mice with drugs that target these proteins we intend to identify the most effective treatments for human leukaemias associated with c-Cbl mutations.

Funding Amount $AUD 535,416.22

Funding Scheme Project Grants

Notes Standard Project Grant