Targeting epigenetic pathways that lead to diabetic complications [ 2018 - ]

Research Grant

Researchers: Prof Mark Cooper (Principal investigator) ,  Prof Assam El-Osta ,  Prof Karin Jandeleit-Dahm ,  Prof Susan Quaggin

Brief description Glucose remains the major cause of complications in diabetes with prior episodes of high glucose having long lasting effects on blood vessels leading to heart attacks, kidney disease and blindness. We have identified an enzyme Set7 which plays a key role in promoting glucose induced injury. By validating this target using drug and molecular approaches we will strengthen the rationale to develop potent inhibitors of this enzyme in order to reduce the major burden of diabetes, its complications.

Funding Amount $989,948.00

Funding Scheme Project Grants

Notes Standard Project Grant