Targeting the defective airway macrophage function in chronic obstructive pulmonary disease (COPD): a new therapeutic approach [ 2016 - ]

Research Grant

Researchers: Prof Sandra Hodge (Principal investigator) ,  Prof Paul Reynolds

Brief description COPD/emphysema is smoking-related, incurable and a leading cause of death. New treatments are urgently needed. We have reported that airway phagocyte dysfunction and inflammation in COPD or smoke-exposed mice can be improved by novel treatments including lectins and macrolide antibiotics. We now show that these effects can be greatly improved by low-dose aspirin. We will further investigate these therapies and also novel antibiotics that have been modified to lose their anti-bacterial activity

Funding Amount $710,928.00

Funding Scheme Project Grants

Notes Standard Project Grant