Targeting cytokine signalling in systemic lupus erythematosus [ 2018 - 2021 ]

Research Grant

Researchers: Dr Anthony Sadler (Principal investigator) ,  Dr Dakang Xu ,  Prof Bryan Williams

Brief description Systemic lupus erythematosus is a disease where the immune system attacks normally healthy tissues. The spontaneous overproduction of signalling molecules called interferons in lupus plays an important role in the severity of the disease. We have found that two proteins, named Bcl6 and PLZF, are important in controlling the interferon response in lupus patients. We propose that identifying how these proteins act to control interferon will aid in developing new treatments for lupus.

Funding Amount $AUD 930,472.36

Funding Scheme Project Grants

Notes Standard Project Grant