TARGETING THE CHK1-STAT3-CIP2A AXIS TO TREAT GLIOBLASTOMA (GBM) [ 2015 - ]

Research Grant

Researchers: Dr Anchit Khanna (Principal investigator)

Brief description Glioblastoma (GBM is a high-grade brain tumour for which current treatments are inadequate. Tumour recurrence is almost inevitable and average life expectancy is measured in months. We have identified a DNA-damage signalling pathway and demonstrated that perturbation of the pathway significantly reduces tumour growth. We plan to target key proteins of the recently identified pathway and validate these findings using tumour cells directly from GBM patients and relevant animal models of human GBM.

Funding Amount $309,436.00

Funding Scheme Early Career Fellowships

Notes Peter Doherty Biomedical ECF