Targeting the CDA1 axis to confer renoprotection [ 2014 - 2016 ]

Research Grant

Researchers: Prof Mark Cooper (Principal investigator) ,  Dr Zhonglin Chai

Brief description We have validated CDA1 as an effective target to retard kidney disease in diabetes using a mouse model where we deleted the CDA1gene. We have also developed a novel agent to inhibit CDA1 in order to retard diabetic kidney disease. In this application, we propose to confirm the efficacy of targeting CDA1 using various diabetes models and a range of strategies to target CDA1. We will also rigorously explore translation of these findings to a new treatment for diabetic renal disease.

Funding Amount $AUD 663,050.39

Funding Scheme Project Grants

Notes Standard Project Grant