Targeting autophagy to improve protein metabolism in ALS [ 2016 - ]

Research Grant

Researchers: A/Pr Bradley Turner (Principal investigator) ,  Prof Kevin Talbot ,  Prof Philip Beart

Brief description One common feature of MND is the accumulation of protein deposits inside nerve cells which leads to their death. We have identified a potent drug which enhances autophagy, a protective process which breaks down protein deposits inside cells. We have shown that this autophagy enhancer efficiently clears protein deposits linked to MND in the Petri dish. We propose to treat MND mice with this autophagy enhancer and predict that it will slow disease signs, preserve lifespan and protect nerve cells.

Funding Amount $586,001.00

Funding Scheme Project Grants

Notes Standard Project Grant