Targeting the AGE-RAGE axis in diabetes associated atherosclerosis [ 2010 - 2012 ]

Research Grant

Researchers: Prof Karin Jandeleit-Dahm (Principal investigator) ,  Prof Angelika Bierhaus ,  Prof Merlin Thomas

Brief description Based on extensive preliminary data we porpose that the AGE intercation with RAGE plays an important role in diabetes associated atherosclerosis. We will perform studies using a soluble form of the receptor RAGE which will trap AGEs in the blood and tissues and thus prevent diabetes related blood vessel damage. Furthermore, we will investigate if RAGE receptor on inflammatory cells such as macrophages plays a pivotal role in blood vessel injury in diabetes.

Funding Amount $AUD 542,859.78

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant