Targeting the Achilles' heel of polymyxins: eliminating the nephrotoxicity [ 2015 - 2017 ]

Research Grant

Researchers: Prof Jian Li (Principal investigator) ,  Dr Tony Velkov ,  Prof Philip Thompson ,  Prof Roger Nation

Brief description The world is facing a growing threat from the emergence of bacterial 'superbugs' that are resistant to all current antibiotics except the polymyxins. However, kidney toxicity occurs in up to 60% of patients receiving intravenous polymyxins. In this project, we will examine how polymyxins cause kidney toxicity then employ the obtained mechanistic information to decrease this adverse effect. Our study targets the urgent global unmet medical need, lack of new antibiotics for bacterial ‘superbugs’.

Funding Amount $AUD 673,420.45

Funding Scheme Project Grants

Notes Standard Project Grant