grant

Targeted inhibition of polyamine synthesis for treatment of childhood neuroblastoma [ 2011 - 2013 ]

Also known as: Switching off polyamine production as a novel form of therapy for childhood neuroblastoma

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1006487]

Researchers: Prof Michelle Haber (Principal investigator) ,  A/Pr David Ziegler Prof Murray Norris

Brief description The childhood cancer, neuroblastoma, frequently has a dismal outcome despite the use of intensive therapy. Polyamines are molecules that are essential for cell survival and these are increased in aggressive neuroblastoma. Using pre-clinical models, we have shown that inhibiting polyamine production can significantly delay neuroblastoma growth. This project aims to improve the overall efficacy of this treatment by targeting multiple steps in polyamine synthesis in combination with chemotherapy.

Funding Amount $AUD 576,605.57

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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