Targeted Inhibition of the FACT (Facilitates Chromatin Transcription) Complex as a Novel Therapeutic Approach in Aggressive Childhood Cancers [ 2015 - 2018 ]

Research Grant

Researchers: A/Pr David Ziegler (Principal investigator) ,  Prof Andrei Gudkov ,  Prof Michelle Haber

Brief description Our research focusses on the most aggressive of all childhood cancers, and our aim is to develop novel therapies for these malignancies. We have discovered a new drug target called "FACT" in aggressive brain and solid tumours of childhood. Targeting FACT with a new class of drugs termed "curaxins" has a powerful anti-tumour effect. We aim to investigate the potential of these drugs as a new, effective therapy for incurable childhood cancers.

Funding Amount $AUD 1,029,488.02

Funding Scheme Project Grants

Notes Standard Project Grant