Targeted development of AMPK ?2-isoform allosteric activators [ 2018 - 2021 ]

Research Grant

Researchers: Dr Jon Oakhill (Principal investigator) ,  Prof Bruce Kemp ,  Prof Jonathan Baell

Brief description Sedentary lifestyles and consumption of high energy foods has led to dramatic increases in the incidence of diseases associated with metabolic dysregulation e.g. type 2 diabetes. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK) which functions as a cellular fuel gauge. We have discovered a new drug that crucially activates the form of AMPK found in metabolically active organs. We aim to develop this drug to unlock new therapeutic opportunity.

Funding Amount $AUD 910,721.46

Funding Scheme Project Grants

Notes Standard Project Grant