grant

Targeted development of AMPK ?2-isoform allosteric activators [ 2018 - 2021 ]

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1145265]

Researchers: Dr Jon Oakhill (Principal investigator) ,  Prof Jonathan Baell Prof Bruce Kemp

Brief description Sedentary lifestyles and consumption of high energy foods has led to dramatic increases in the incidence of diseases associated with metabolic dysregulation e.g. type 2 diabetes. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK) which functions as a cellular fuel gauge. We have discovered a new drug that crucially activates the form of AMPK found in metabolically active organs. We aim to develop this drug to unlock new therapeutic opportunity.

Funding Amount $AUD 910,721.46

Funding Scheme Project Grants

Notes Standard Project Grant

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