Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/204702]Researchers: Dr Chen Au Peh (Principal investigator)
Brief description An effective T cell response (cellular immune response) to infections is vital to a functional immune system. Normally, proteins are cleaved into small molecules called peptides and these peptides are in turn presented by Major Histocompatibility Complex molecules to T cells. However, we have only partial understanding of what determines the choice of peptides that are finally presented to T cells. Recent research suggests that a molecule called tapasin may also influence the choice of peptides. This research proposal aims to examine the role of tapasin in this regard. A thorough understanding of the basic principles of peptide presentation to T cells is crucial to the design of effective vaccines. Furthermore it will also broaden our understanding of immunological responses to cancer, autoimmune diseases and infections.
Funding Amount $AUD 226,650.00
Funding Scheme NHMRC Project Grants
Notes New Investigator Grant
- nhmrc : 204702
- PURL : https://purl.org/au-research/grants/nhmrc/204702
