Systems pharmacology of cystic fibrosis transmembrane regulator correctors and potentiators [ 2019 - ]

Research Grant

Researchers: Dr Elena Schneider (Principal investigator)

Brief description Cystic fibrosis is a life limiting disease caused by defective or deficient cystic fibrosis trans-membrane conductance regulator activity. The recent approval of lumacaftor combined with ivacaftor targets 70% of CF patients with F508del-CFTR. Unfortunately, the clinical efficacy of these first-in-class drugs is limited by our limited understanding of their pharmacology. This innovative systems pharmacology project will have a significant potential in improving clinical practice worldwide.

Funding Amount $327,192.00

Funding Scheme Early Career Fellowships

Notes Peter Doherty Biomedical ECF