grant

Synthetic lethality screen targeting a defective checkpoint in melanoma [ 2012 - 2015 ]

Also known as: Targeting defective growth controls in cancer

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1029260]

Researchers: Prof Brian Gabrielli (Principal investigator)

Brief description All cancers have defects in the mechanisms that regulate normal cell growth and division. These defects provide a growth advantage for the cancer, but can also be an Achilles Heel. In this project we will investigate targeting a defective control mechanism we found in a high proportion of melanomas. We will identify genes that when inhibited combine with the defective control to specifically kill tumour cells with this defect. Normal tissue is protected by its intact regulatory mechanism.

Funding Amount $AUD 552,121.50

Funding Scheme Project Grants

Notes Standard Project Grant

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Identifiers
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ACN 633 798 857