Synchrotron X-ray assessment of airway surface physiology for cystic fibrosis [ 2010 - 2014 ]

Research Grant

[Cite as]

Researchers: A/Pr David Parsons (Principal investigator) ,  A/Pr William Skinner Dr Karen Siu Dr Martin Donnelley

Brief description We seek a cure or long-lasting therapy for the fatal airway disease in cystic fibrosis. Disease is caused by a shallow and dehydrated airway surface liquid (ASL), allowing bacteria to infect the lung. We can introduce a corrective gene into mouse airways where it can be effective for over 1 yr, but no fast, accurate and non-invasive measurement exists to test if treatments are successful. We will develop methods using synchrotron light to directly measure ASL depth changes in live mouse airways.

Funding Amount $AUD 778,228.83

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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