grant

Susceptibility of the basal layer of human epidermis to UVA oxidative damage due to pheomelanin and suboptimal DNA repair [ 2011 - 2014 ]

Also known as: UVA-induced oxidative damage in human skin

Funded by National Health and Medical Research Council
Managed by The University of Sydney
Managed by University of Sydney
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1009021]

Researchers: Prof Gary Halliday (Principal investigator) ,  A/Pr James Guy Lyons

Brief description Australia has the highest incidence of skin cancer in the world. It is important to understand how sunlight causes skin cancer and the wavelengths involved in order to devise effective preventative and therapeutic strategies. Our proposal is that the cells in the skin that give rise to the most common forms of skin cancer, squamous cell carcinoma and basal cell carcinoma, are particularly vulnerable to UVA. We aim to study why this is the case and whether this vulnerability can be prevented.

Funding Amount $AUD 559,354.28

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Medical and Health Sciences | Oncology and Carcinogenesis | Solid Tumours | keratinocytes | melanocyte | melanoma | skin cancer | solar keratosis | squamous cell carcinoma | sun exposure | sun protection | sunlight | ultraviolet (UV) radiation |
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