Suppressing MDM4 in melanoma [ 2014 - ]

Research Grant

Researchers: Prof Mark Shackleton (Principal investigator) ,  Prof Chris Marine

Brief description We recently discovered a new way to treat melanoma by inhibiting a protein called MDM4 that is important in promoting tumor growth in ~2/3 of melanomas. In this proposal, we will extend this work to see if anti-MDM4 therapy is effective in laboratory models that are more relevant to patients and in combination with other melanoma therapies. We will also explore additional ways of inhibiting MDM4 that may make anti-MDM4 therapy even more potent.

Funding Amount $640,558.00

Funding Scheme Project Grants

Notes Standard Project Grant