grant

Studying the interaction of Reelin deficiency and environmental factors in the development of schizophrenia using animal behavioural models [ 2011 - 2013 ]

Also known as: Reelin gene and environment interaction in schizophrenia

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1004129]

Researchers: Prof Maarten Van Den Buuse (Principal investigator) ,  A/Pr Jeffrey Craig ,  Dr Rachel Hill

Brief description Schizophrenia is caused by an interaction of genetic predisposition and environmental risk factors such as stress or drug abuse. Reelin is a protein involved in the normal development of the brain but its levels are markedly reduced in schizophrenia. We will use mice with low levels of reelin in their brain and assess the effect of environmental stress and drugs of abuse. These studies could elucidate gene-environment interaction in schizophrenia and lead to new treatment strategies.

Funding Amount $AUD 438,695.67

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Central Nervous System | Medical and Health Sciences | Neurosciences | development | dopamine | drug abuse | epigenetics | glutamate receptors | schizophrenia and related disorders | sex differences | stress |
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