grant

A study of the role of voltage-gated potassium channels in the process of phototransduction, in the setting of photoreceptor sensitivity levels and response times, and in the progression of a distinctive form of inherited retinal dystrophy [ 2012 - 2015 ]

Also known as: The role of potassium channels in photoreceptor function

Funded by National Health and Medical Research Council
Funded by National Health and Medical Research Council (Australia)
Funded by National Health and Medical Research Council (NHMRC)
Managed by The University of Western Australia
Managed by University of Western Australia
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1029740]

Researchers: Prof David Hunt (Principal investigator) ,  A/Pr Nathan Hart ,  Prof Brian Key ,  Prof Shaun Collin

Brief description Inherited retinal disease is a major cause of blindness but the genetic basis is extremely heterogeneous. One such disorder, cone dystrophy with supernormal rod ERG, arises from mutations in KCNV2 that encodes a potassium voltage-gated channel protein. The objective of the project is to use animal models of the disease to determine the role of this channel protein in normal visual function and to assess the impact of loss of function on retinal development and function.

Funding Amount $AUD 360,371.25

Funding Scheme Project Grants

Notes New Investigator Grant

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Subjects
Medical and Health Sciences | Neurosciences | Sensory Systems | blindness | inherited | mouse models | photoreceptors | potassium channels | retinal dystrophy | vision loss | zebrafish |
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