Studies on the effects of endogenous and exogenous opioids in modulating exercise-induced dyspnoea in people with moderate / severe chronic obstructive pulmonary disease (COPD). Two double-blind randomised, placebo controlled trials. [ 2014 - 2016 ]

Research Grant

Researchers: Prof David Currow (Principal investigator) ,  Dr Donald Mahler ,  Dr Timothy To ,  Prof Amy Abernethy ,  Prof Linda Denehy
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Brief description There is evidence that morphine-like chemicals made by the body itself help reduce breathlessness. It is not clear whether this response is because of the effects of these morphine-like chemicals on the brain, in the lung or both. This study will help understand where these chemicals act to reduce breathlessness in people with emphysema during exercise. Subsequently, it will also help to understand whether small, regular doses of morphine safely further reduce breathlessness during exercise.

Funding Amount $AUD 197,086.65

Funding Scheme Project Grants

Notes Standard Project Grant