grant

Structure and interactions of a disordered malaria surface protein: implications for antigenicity [ 2010 - 2012 ]

Also known as: Immune recognition of a malaria vaccine candidate

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/637368]

Researchers: Prof Raymond Norton (Principal investigator) ,  Robin Anders

Brief description Malaria is responsible for around 2 million deaths annually, many in children under 5 years of age. Merozoite surface protein 2 (MSP2) from Plasmodium falciparum is being developed as a vaccine candidate. We will investigate the structure of MSP2 in various environments, including when bound to inhibitory antibodies. Key goals are to understand how the disordered structure of MSP2 affects its interaction with the host immune system and how that information can be used to design better vaccines.

Funding Amount $AUD 511,020.80

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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