Structure-function of type I interferon receptors: informing the basis for selective modulation of signal transduction and function [ 2017 - 2021 ]

Research Grant

Researchers: Prof Paul Hertzog (Principal investigator) ,  Dr Julian Vivian ,  Dr Nicole De Weerd

Brief description Interferons (IFNs) are a family of proteins with critical roles in infectious and inflammatory diseases and cancers. Currently we do not understand why there are so many type I IFNs, their different functions and how they are achieved. This project will determine at a fine molecular level how different IFNs interact with molecules on target cells and transmit particular signals. We will focus on a novel IFN? that we discovered. These studies will underpin the development of new therapies.

Funding Amount $AUD 1,349,395.67

Funding Scheme Project Grants

Notes Standard Project Grant