Structure and composition of the pre-T cell receptor-CD3 complex [ 2012 - 2015 ]

Research Grant

Researchers: Dr Richard Berry (Principal investigator)

Brief description In order to recognize a wide variety of pathogens, humans produce many different T cell receptors (TCRs) by the process of gene-rearrangement. However, gene-rearrangement may not always lead to a functioning TCR. We are studying the pre-TCR protein that is responsible for monitoring the success of gene-rearrangement and is thus essential for the formation of a robust immune system. Understanding pre-TCR function will lead to new treatments for immune related diseases.

Funding Amount $AUD 307,946.17

Funding Scheme Early Career Fellowships

Notes Peter Doherty Biomedical ECF