Structure and biophysical analysis aided design of novel toxoid vaccines for a major class of bacterial toxins. [ 1/1/2021 - 12/31/2023 ]

Research Grant

Brief description Inactivated bacterial toxins (toxoids), such as the tetanus vaccine, are safe and effective vaccines. Cholesterol dependent cytolysins (CDCs) are bacterial toxins produced by many important human pathogens including Group A Streptococcus (GAS) and Pneumococcus. GAS has no available vaccine and Pneumococcus does not have a universal vaccine. We have developed a new way of inactivating CDCs based on new knowledge of how they target human cells and will use this knowledge to make new vaccines.

Funding Amount $608,425

Funding Scheme Ideas Grants

Chief Investigator Prof Michael Jennings

Notes Ideas Grants