Structural studies on the immune effector perforin: developing mechanism-based inhibitors [ 2016 - 2019 ]

Research Grant

Researchers: Prof James Whisstock (Principal investigator) ,  Prof Raymond Norton (Principal investigator) ,  A/Pr Ilia Voskoboinik ,  Dr Ruby Law

Brief description Perforin is an essential weapon deployed by the human immune cells in order to destroy virally infected or cancerous cells. Despite this key role, unwanted or excessive perforin function can result in disease and can severely impact on successful treatment of leukaemia through bone marrow transplantation. This application aims to understand the molecular details of perforin function, and to apply this knowledge to develop perforin inhibitors.

Funding Amount $AUD 1,150,639.73

Funding Scheme Project Grants

Notes Standard Project Grant