Structural studies on cell signalling via the LIF receptor and gp130 [ 2008 - 2010 ]

Also known as: Understanding cell signalling by cytokines of the IL-6-LIF family which act through LIFR.

Research Grant

[Cite as]

Researchers: Dr Thomas Garrett (Principal investigator) ,  A/Pr James Murphy A/Pr Sandra Nicholson Dr Jian-Guo Zhang

Brief description The cytokines play important roles in the immune system during blood cell development and inflammation, and in nerve growth, bone remodeling, reproduction and heart development. Cell responses are initiated by a cytokine bringing together on the cell surface a receptor complex made up of multiple molecules. This project will investigate the atomic structure of the cell surface macromolecular complex, and hence the underlying mechanism by which cytokine signals are initiated.

Funding Amount $AUD 453,943.35

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

Click to explore relationships graph
Viewed: [[ro.stat.viewed]]