Structural studies on cell signalling via the LIF receptor and gp130 [ 2008 - 2010 ]

Research Grant

Researchers: Dr Thomas Garrett (Principal investigator) ,  A/Pr James Murphy ,  A/Pr Sandra Nicholson ,  Dr Jian-Guo Zhang

Brief description The cytokines play important roles in the immune system during blood cell development and inflammation, and in nerve growth, bone remodeling, reproduction and heart development. Cell responses are initiated by a cytokine bringing together on the cell surface a receptor complex made up of multiple molecules. This project will investigate the atomic structure of the cell surface macromolecular complex, and hence the underlying mechanism by which cytokine signals are initiated.

Funding Amount $AUD 453,943.35

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant