grant

Structural investigations of bacterial evasion of IgA mucosal and systemic immunity [ 2009 - 2013 ]

Also known as: Bacterial evasion of IgA immunity

Funded by National Health and Medical Research Council
Managed by Macfarlane Burnet Institute for Medical Research and Public Health
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/543317]

Researchers: A/Pr Paul Ramsland (Principal investigator) ,  Dr Bruce Wines

Brief description Nose, throat and skin infections are often caused by streptococcal and staphylococcal bacteria, known as Strep Throat and Golden Staph. Infections can be life-threatening in newborns, the elderly or individuals with weak immune systems. These bacteria make proteins bind and inactivate immune proteins. Our research examines the structural basis for bacterial interactions with a key immune system protein (an antibody called IgA) and may lead to new prevention and treatment strategies.

Funding Amount $AUD 488,812.72

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biomedical and Clinical Sciences | Bacterial binding proteins | Bacterial infection prevention and treatment | Bacterial virulence factors | Clinical Sciences | Clinical Sciences Not Elsewhere Classified | Crystallography and small-angle scattering | IgA mediated immunity | IgA mucosal and systemic immunity | Immune evasion | Mucosal bacterial pathogens | Streptococcal and Staphylococcal infections | Structural biology |
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