Structural and functional characterisation of the microtubule-binding protein DCLK1 [ 2019 - ]

Research Grant

Brief description The serine/threonine kinase doublecortin-like kinase 1 (DCLK1) is a bi-functional protein that regulates the assembly of microtubules. Recently, DCLK1 dysfunction has been linked to tumorigenesis. This proposal focuses on elucidating the molecular basis of DCLK1 dysfunction. A better understanding at the molecular level of how DCLK1 conformational state dictate its microtubule scaffolding function and signal output may provide crucial insights into developing novel therapeutics strategies.

Funding Amount $547,324.00

Funding Scheme Project Grants

Notes Standard Project Grant