Structural and functional characterisation of the oncogene P-Rex1 [ 2017 - ]

Research Grant

Researchers: Dr Andrew Ellisdon (Principal investigator) ,  A/Pr Hans Elmlund ,  Dr Michelle Halls ,  Prof James Whisstock

Brief description The spread of cancer to other parts of the body (metastasis) is a major cause of mortality. The characterisation of proteins that regulate metastasis is therefore a priority. P-Rex1 plays a crucial role in promoting metastasis in breast and other cancers. We will determine the structural basis of P-Rex1 activity, and investigate how its dysregulation promotes aberrant cell growth. This study will provide the knowledge to build future drug development programs targeting P-Rex1 in cancer.

Funding Amount $623,447.00

Funding Scheme Project Grants

Notes Standard Project Grant