grant

Structural and functional characterisation of human neurotransmitter inhibitor producing enzymes glutamate decarboxylase [ 2009 - 2010 ]

Also known as: Structural and functional analysis of human glutamate decarboxylase

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/579722]

Researchers: Dr Christopher Langendorf (Principal investigator)

Brief description Glutamate decarboxylase (GAD) produces the major inhibitory neurotransmitter in the central nervous system, GABA. GAD dysfunction is associated with mental diseases including epilepsy and schizophrenia. We aim to understand the functional role of structural elements of GAD via x-ray crystallography and kinetic studies. We also aim to produce a high throughput GAD enzyme assay to screen compounds that can modulate GAD activity, which could be potential therapeutic targets for related disease.

Funding Amount $AUD 35,085.90

Funding Scheme NHMRC Postgraduate Scholarships

Notes Dora Lush Biomedical Postgraduate Scholarship

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Identifiers
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ACN 633 798 857