grant

A structural and functional basis for the regulation of gene expression by nuclear retention of RNA [ 2008 - 2011 ]

Also known as: How protein and RNA molecules interact to regulate gene expression

Funded by National Health and Medical Research Council
Managed by The University of Western Australia
Managed by University of Western Australia
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/513880]

Researchers: Prof Charles Bond (Principal investigator) ,  Dr Archa Fox

Brief description The nuclear retention mechanism is a novel way used by cells to control which genes are made into proteins - a fundamental process for all diseases, particularly cancers. This project will employ cutting edge structural and proteomic techniques to determine the molecular details underpinning nuclear retention. These insights will be important for the development of new tissue-restricted gene therapy applications and drugs targeting the cancers that rely on this mechanism.

Funding Amount $AUD 504,097.08

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
270201 | RNA binding proteins | cancer | control of gene expression | gene expression | gene structure-protein function-novel drug therapies | gene therapy | nuclear organisation | protein structure | proteomics |
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