Structural characterization of novel AB5 cytotoxin - SubAB [ 2008 - 2010 ]

Research Grant

Researchers: Dr Travis Beddoe (Principal investigator) ,  Prof Adrienne Paton

Brief description AB5 toxins are virulence factors from a range of pathogenic bacteria, including Shiga toxigenic E. coli (STEC), S. dysenteriae, V. cholerae, and B. pertussis. AB5 toxins comprise a catalytic A subunit that disrupts distinct essential cellular processes within the cell and a receptor binding, pentameric B subunit that enables the toxin to target certain cell types. We are structural characterizing a novel AB5 toxin that targets an essential component of the cellular machinery.

Funding Amount $AUD 445,011.35

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant