Structural characterisation of phosphopeptide recognition by FHA domains [ 2001 - 2003 ]

Research Grant

Researchers: Prof Bostjan Kobe (Principal investigator) ,  Prof Helen Blanchard

Brief description Cells require numerous signalling pathways to keep various cellular processes coordinated and under control. One of the most important aspects of signalling is formation of complexes involving two or more different proteins. One of the recently identified players in the formation of these signalling complexes is the so-called forkhead-associated (FHA) module, FHA modules are protein sequences of ~130 amino acids that appear as a part of signalling proteins and bind to specific sequences on signalling protein partners. Many proteins containing FHA modules are important for the repair of damaged DNA and the stability of chromosomes. The aim of our studies is to understand the molecular and atomic details of how FHA modules bind their partners. This is the first step towards designing therapeutic agents against various forms of cancer where DNA is damaged.

Funding Amount $AUD 257,036.72

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant