Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/606557]Researchers: Prof James Whisstock (Principal investigator) , A/Pr Ilia Voskoboinik , Prof Joseph Trapani
Brief description This proposal focuses upon understanding the structure and mechanism of perforin, a protein that performs a crucial role in human immunity. We will investigate how certain mutations in perforin cause deficiency and disease. Our work will also seek to understand how potential therapeutics act to modulate perforin function. Finally, through a combination of biochemical and structural studies we will elucidate the details of perforin mechanism.
Funding Amount $AUD 876,678.63
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 606557
- PURL : https://purl.org/au-research/grants/nhmrc/606557
