Structural Basis of Substrate Recognition by the Membrane-Associated E3 Ubiquitin Ligases [ 2012 - 2014 ]

Research Grant

Researchers: A/Pr Matthew Call (Principal investigator) ,  Dr Melissa Call

Brief description Membrane-associated E3 ubiquitin ligases control cellular levels of important immunoregulatory molecules and occur in both host- and virus-encoded forms. Target selectivity maps to the transmembrane domains of ligases and their substrates in a little-studied mode of intramembrane molecular recognition. Our goal is to determine the physical basis of this interaction by establishing which sequences drive the association and providing atomic-resolution structures of the membrane-embedded complexes.

Funding Amount $AUD 415,244.51

Funding Scheme Project Grants

Notes Standard Project Grant