grant

The structural basis of the interaction of human relaxins with their receptors. [ 2008 - 2010 ]

Also known as: Structure-function relationship of human relaxins.

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/508995]

Researchers: Prof John Wade (Principal investigator) ,  A/Pr Richard Hughes Prof Geoffrey Tregear Prof Ross Bathgate

Brief description Relaxin is a peptide that is involved in the regulation of the birth process. It has considerable promise as an anti-fibrotic agent. Recently, another relaxin-like peptide, relaxin-3, was identified and shown to be brain-specific. It modulates the stress response and appetite. Both relaxins act upon different receptors to elicit their biological effects. To exploit their clinical potential, we will determine how these peptides selectively bind and ativate their individual receptors.

Funding Amount $AUD 573,807.21

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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