The structural basis for biased agonism at the glucagon-like peptide-1 receptor [ 2017 - ]

Research Grant

Researchers: Dr Denise Wootten (Principal investigator) ,  Prof Laurence Miller

Brief description The glucagon-like peptide-1 receptor plays an essential role in nutrient-regulated insulin release, and is a major target for therapeutic treatment of type 2 diabetes. The binding of different drugs to this receptor can promote distinct signalling profiles inside the cell that can lead to different physiological outcomes. Understanding the mechanistic basis for this will provide a framework to enable rational design of novel, better and safer therapeutics for the treatment of diabetes.

Funding Amount $872,536.00

Funding Scheme Project Grants

Notes Standard Project Grant