Stress-induced genomic instability as a driver of adaptive responses in human cancer cells [ 2015 - 2017 ]

Research Grant

Researchers: Prof David Thomas (Principal investigator) ,  Dr Arcadi Cipponi ,  Dr David Goode

Brief description Growing experimental evidence suggests human cancer cells use evolutionary conserved programs to regulate their mutation rates in response to pharmacological agents, accelerating adaptation and the emergence of resistance. The purpose of our study is to identify the common molecular pathways and genetic mechanisms driving the regulation of mutation rates. Targeting of these pathways using a new generation of “anti-evolution” drugs is an attractive possibility for novel therapeutic approaches.

Funding Amount $AUD 690,426.71

Funding Scheme Project Grants

Notes Standard Project Grant