Strategies to achieve kidney transplant tolerance in a clinically-relevant model [ 2012 - 2015 ]

Research Grant

Researchers: A/Pr Alexandra Sharland (Principal investigator) ,  A/Pr Huiling Wu ,  Dr Alex Bishop ,  Prof Steven Chadban

Brief description The acceptance of kidney transplants without immunosuppression (tolerance) would avoid the side effects of these powerful drugs and improve long-term graft survival. Donor brain death causes inflammation in transplanted kidneys which can block tolerance. In this project, we aim to determine whether expression of a naturally-occurring soluble anti-inflammatory molecule in the liver can prevent this inflammation, allowing tolerance to develop.

Funding Amount $AUD 663,490.68

Funding Scheme Project Grants

Notes Standard Project Grant