How stimulant laxatives work [ 2018 - 2020 ]

Research Grant

Researchers: Prof Simon Brookes (Principal investigator) ,  A/Pr Philip Dinning ,  Prof Marcello Costa

Brief description Stimulant laxatives are widely used and usually very effective in the short term, but how they work is very poorly understood. Our recent work has shown that they selectively excite sensory pathways from the colon which then trigger defaecation. This points to an undiscovered mechanism that potently affects colonic sensation and motility. This is likely to be a target for new treatments for other colonic disorders such as Irritable bowel syndrome and faecal incontinence.

Funding Amount $AUD 536,839.98

Funding Scheme Project Grants

Notes Standard Project Grant