Spatial organization of Lck as a regulatory mechanism of TCR signalling [ 2014 - 2017 ]

Also known as: How the organization of the cell membrane determines T lymphocytes activation

Research Grant

[Cite as]

Researchers: Dr Jeremie Rossy (Principal investigator) ,  Dr Yann Gambin (Principal investigator) ,  A/Pr Daniel Hatters

Brief description To function in an immune response, T cell become activated when the interactions between the T cell receptor and the kinase Lck on the cell surface results in intracellular signals. Here, we will investigate how the kinase is organized on the cell surface during receptor activation and what intrinsic and extrinsic parameters regulate its organization. The research is based on novel single molecule imaging tools and will provide new insights into the regulation of T cell activation.

Funding Amount $AUD 601,263.79

Funding Scheme Project Grants

Notes Standard Project Grant

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