grant

Sortilin forms a complex with APP and BACE to regulate Abeta production [ 2012 - 2014 ]

Also known as: Roles of sortilin/APP/BACE complex in Alzheimer's disease

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1037776]

Researchers: Dr Jia Liu (Principal investigator)

Brief description Alzheimer's disease is a neurodegenerative disorder which is highly prevalent in aging population. Amyloid beta is a toxic peptide derived from a metabolic processing of its precursor amyloid precursor protein (APP). This project will examine how a novel protein called sortilin interacts with APP and its processing enzyme and how the toxic peptide is produced. Understanding the trafficking of APP and beta-secretase ?BACE? regulated by sortilin may help understanding how Alzheimer's disease is developed.

Funding Amount $AUD 208,910.98

Funding Scheme Early Career Fellowships

Notes Australia-China Exchange ECF

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Identifiers
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ACN 633 798 857