Somatic gene trapping in Schistosoma mansoni _ the key to functional analysis [ 2011 - 2014 ]

Research Grant

Researchers: A/Pr Bernd Kalinna (Principal investigator) ,  Prof Robin Gasser

Brief description Blood flukes are endemic in 76 countries and infect 300 million people worldwide. Control largely relies on the drug praziquantel. However, its wide scale use has led to concerns that drug resistance will develop. In this study we will use ñgene trap vectorsî to introduce insertional mutations into the schistosome genome. This will help to understand the function and importance of genes in biochemical pathways used by the parasite and to define effective targets for drug and vaccine development.

Funding Amount $AUD 623,270.35

Funding Scheme Project Grants

Notes Standard Project Grant