Soluble endoglin in the pathogenesis of preeclampsia: investigation of mechanisms and the development of therapeutics [ 2013 - 2015 ]

Research Grant

Researchers: Dr Tu'Uhevaha Kaitu'U-Lino (Principal investigator)

Brief description Preeclampsia is a severe disease of pregnancy. As the pathogenesis is poorly understood, the only treatment is for clinicians to deliver babies irrespective of gestation. We have identified MMP-14 as the molecular scissors that release soluble endoglin from placenta, a toxin centrally responsible for severe preeclampsia. In this project we aim to further investigate the mechanisms governing soluble endoglin release and to begin developing a potential therapeutic for use in the clinic.

Funding Amount $AUD 572,733.55

Funding Scheme Project Grants

Notes New Investigator Grant