grant

Smad3 acetylation modulates organ fibrosis [ 2014 - 2016 ]

Also known as: Smad3 acetylation and fibrosis

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1057581]

Researchers: A/Pr Jinhua Li (Principal investigator) ,  A/Pr David Nikolic-Paterson

Brief description Fibrosis is a major mechanism driving chronic disease. A specific pathologic process (TGF/Smad signalling) plays an important role in scarring of the kidney and the heart; but our understanding of this process is limited. Our exciting new data has identified a chemical modification of a component of this scarring pathway (acetylation of Smad3), and this project seeks to determine whether this modification plays a pivotal role in regulating tissue scarring.

Funding Amount $AUD 683,040.36

Funding Scheme Project Grants

Notes Standard Project Grant

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Identifiers
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ACN 633 798 857