Skeletal Disease in a Dish: Using novel in vitro disease models produced from patient induced pluripotent stem cells to reveal pathogenic mechanisms and explore treatments for genetic skeletal disorders [ 2018 - ]

Research Grant

Researchers: Prof John Bateman (Principal investigator) ,  A/Pr Shireen Lamande ,  Prof Andrew Elefanty ,  Prof Ravi Savarirayan

Brief description Inherited skeletal disorders are a significant disease burden. Many gene mutations have been defined but we only have limited understanding about how they cause the disease. We will use patient skin cells and a new in vitro cell reprogramming technology to induce them to form cartilage and bone cells to produce mutation-specific “disease in a dish” models. These models will allow us to answer questions about how specific mutations cause disease and test novel drug therapies

Funding Amount $797,389.00

Funding Scheme Project Grants

Notes Standard Project Grant