A single nucleotide resolution map of a cancer associated neochromosome [ 2011 - 2013 ]

Research Grant

Researchers: Prof David Thomas (Principal investigator) ,  Prof Anthony Papenfuss

Brief description Neochromosomes (NCs) are large chromosomes which are not usually found in a normal cell. Well differentiated liposarcoma (WDLPS) is a tumour which is almost universally associated with the presence of NCs. We are using the approach of purifying the NC from a series of WDLPS cell lines, and using new techniques to derive the DNA sequence of the neochromosome. We will use this information to identify the genetic factors on the NC which are involved in the initiation or progression of WDLPS.

Funding Amount $AUD 567,350.82

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant