A single fibre approach to the study of regulation of protein synthesis in skeletal muscle [ 2007 - 2009 ]

Research Grant

Researchers: Prof D. George Stephenson (Principal investigator) ,  Dr Markandeya Jois

Brief description Skeletal muscle is the most abundant tissue in the human body and accounts for more than 40% of body weight. Loss of muscle mass is a major cause of frailty and loss of functionality in the elderly and is also a common feature of many chronic diseases such as cancer, HIV, arthritis and chronic heart failure. Changes in protein synthesis are intrinsically associated with alterations in muscle mass, which is integral to health, physical performance and independent living. In this project we aim to answer some important outstanding questions regarding the regulation of protein synthesis in mammalian skeletal muscle using a novel, single cell approach. Results obtained within the framework of the project will contribute to the understanding of the regulation of cellular and molecular events underpinning protein synthesis in muscle, which is critical for developing effective strategies of treatment and management of various medical conditions to prevent muscle wasting.

Funding Amount $AUD 420,039.34

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant