Single-Beat Preload Recruitable Stroke Work measurement of cardiac contractility in three mammalian models. [ 2002 - 2004 ]

Research Grant

Researchers: Prof Michael Feneley (Principal investigator) ,  Dr Phillip Spratt ,  Prof Peter Macdonald

Brief description The accurate measurement of the inherent pumping capacity of the heart muscle is difficult because (i) most measurements currently in use cannot accurately discriminate between the contribution of the heart muscle and that of the vascular system to the results obtained, and (ii) the measurements which can discriminate currently require invasive measurements and procedures that frequently restrict their use. The overall purpose of this proposal is to more rigorously validate a promising method we have developed that will (i) make accurate assessment possible from a single cardiac beat in both experimental animals and human subjects; (ii) reduce the number of experimental animals required for such measurements by permitting sequential measurements in the same animals; (iii) make it possible to perform such measurements non-invasively in human subjects.

Funding Amount $AUD 241,980.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant